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Background The routine determination of drug resistance in newly HIV-1 infected individuals documents a potential increase in the transmission of drug-resistant variants. Plasma samples from twenty seven therapy naive…
Updated Oct 29, 2026
HealthData.Gov
Background Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia.…
Updated Oct 29, 2026
HealthData.Gov
Background Alternative mRNA splicing of αi2, a heterotrimeric G protein α subunit, has been shown to produce an additional protein, termed sαi2. In the sαi2 splice variant, 35 novel amino acids replace the normal…
Updated Oct 29, 2026
HealthData.Gov
Background SP100 is a nuclear protein that displays a number of alternative splice variants. In Old World monkeys, apes and humans one of these variants is extended by a retroprocessed pseudogene, HMG1L3, whose…
Updated Oct 29, 2026
HealthData.Gov
Background Although previous research has demonstrated that referral to pre-dialysis clinics is associated with favourable objective outcomes, the benefit of a pre-dialysis clinic from the perspective of…
Updated Oct 29, 2026
HealthData.Gov
Background Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking…
Updated Oct 29, 2026
HealthData.Gov
Ventilating patients with acute respiratory failure according to standardized recommendations can lead to varying volume–pressure (V-P) relationships and overdistension. Young children may be more susceptible than…
Updated Oct 29, 2026
HealthData.Gov
Background Virulence genes on Salmonella pathogenicity island 1 (SPI1) are coordinately regulated by HilA, a member of the OmpR/ToxR family of transcription factors. Although a great deal is known about the complex…
Updated Oct 29, 2026
HealthData.Gov
In chronic inflammatory foci, such as the rheumatoid joint, there is enhanced recruitment of phagocytes from the blood into the tissues. Chemokines are strongly implicated in directing the migration of these cells,…
Updated Oct 29, 2026
HealthData.Gov
Background Elevated intracranial pressure (ICP) resulting from impaired drainage of cerebrospinal fluid (CSF) causes hydrocephalus with damage to the central nervous system. Clinical symptoms of elevated intracranial…
Updated Oct 29, 2026
HealthData.Gov
Background Information on the effectiveness of elementary school level, tobacco-use prevention programs is generally limited. This study assessed the impact of a structured, one-time intervention that was designed to…
Updated Oct 29, 2026
HealthData.Gov
Nutritional support has become a routine part of the care of the critically ill patient. It is an adjunctive therapy, the main goal of which is to attenuate the development of malnutrition, yet the effectiveness of…
Updated Oct 29, 2026
HealthData.Gov
Background Bacterial infections complicate the course of patients with human immunodeficiency virus infection. The purpose of this study was to describe the bacterial pathogens causing blood stream infection, identify…
Updated Oct 29, 2026
HealthData.Gov
Background Maitotoxin (MTX) initiates cell death by sequentially activating 1) Ca2+ influx via non-selective cation channels, 2) uptake of vital dyes via formation of large pores, and 3) release of lactate…
Updated Oct 29, 2026
HealthData.Gov
Background: Identification of orthologous relationships between genes from widely divergent taxa allows partial reconstruction of the gene complement of ancestral genomes. C2H2 zinc-finger genes are one of the largest…
Updated Oct 29, 2026
HealthData.Gov
The software tool PRESTA (PRomoter EST Association) is designed for efficient recovery of characterized and partially verified promoters from GenBank and EMBL libraries. The PRESTA algorithm demonstrates the principle…
Updated Oct 29, 2026
HealthData.Gov
Background: Hepatic injury after ischemia/reperfusion is attributed to the development of oxygen free radical (OFR)-mediated lipid peroxidation - a process that can be measured through its byproducts, specifically…
Updated Oct 29, 2026
HealthData.Gov
Background A standardised technique using a suction-induced mini-erosion that allows serial sampling of dermal interstitial fluid (IF) for 5 to 6 days has been described. In the present study, we studied permeability…
Updated Oct 29, 2026
HealthData.Gov
The upper airway is an organ not often investigated. Relatively little is known about its complex functions, and misunderstandings abound. The paper by Thomachot et al in this issue provides an opportunity to ponder on…
Updated Oct 29, 2026
HealthData.Gov
According to the Frank-Starling relationship, a patient is a 'responder' to volume expansion only if both ventricles are preload dependent. Mechanical ventilation induces cyclic changes in left ventricular (LV) stroke…
Updated Oct 29, 2026