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Background Ciliates employ massive chromatid breakage and de novo telomere formation during generation of the somatic macronucleus. Positions flanking the 81-MAC locus are reproducibly cut. But those flanking the Common…
Updated Oct 29, 2026
HealthData.Gov
Background Filopodia, retraction fibers and microvilli, are fragile microextensions of the plasma membrane that are easily damaged by mechanical force during specimen preparation for microscopy. To preserve these…
Updated Oct 29, 2026
HealthData.Gov
Background Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated…
Updated Oct 29, 2026
HealthData.Gov
Background Any DNA sequence is a result of compromise between the selection and mutation pressures exerted on it during evolution. It is difficult to estimate the relative influence of each of these pressures on the…
Updated Oct 29, 2026
HealthData.Gov
Background Some complications of childbirth (for example, faecal incontinence) are a source of social embarrassment for women, and are often under reported. Therefore, it was felt important to determine levels of…
Updated Oct 29, 2026
HealthData.Gov
The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials have shown that the benefits of LDL lowering extend…
Updated Oct 29, 2026
HealthData.Gov
Heliox, a mixture of helium and oxygen, has a density that is less than that of air. Breathing heliox leads to a reduction in resistance to flow within the airways, and consequently to a decrease in the work of…
Updated Oct 29, 2026
HealthData.Gov
Background Current efforts to study the genetic underpinnings of higher brain functions have been lacking appropriate phenotypes to describe cognition. One of the problems is that many cognitive concepts for which there…
Updated Oct 29, 2026
HealthData.Gov
Background An association between mumps-measles-rubella (MMR) vaccination and the onset of symptoms typical of autism has recently been suggested. This has led to considerable concern about the safety of the vaccine.…
Updated Oct 29, 2026
HealthData.Gov
Background: Size, weight and technical difficulties limit the use of ponderous strip chart electroencephalographs (EEGs) for real time evaluation of brain wave function in modern intensive care units (ICUs). Portable,…
Updated Oct 29, 2026
HealthData.Gov
Background The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece. Methods This was a prospective study. Diagnosis was based on detailed…
Updated Oct 29, 2026
HealthData.Gov
eHealth Applications in Health Care Management
Updated Oct 29, 2026
HealthData.Gov
Background Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins, BTBD1 and BTBD2, which share 80% amino acid identities. Results The interactions…
Updated Oct 29, 2026
HealthData.Gov
Background The thalassemic syndromes originate from mutations of the globin genes that cause, besides the characteristic clinical picture, also an increased Hb F amount. It is not yet clear if there are more factors,…
Updated Oct 29, 2026
HealthData.Gov
Hepatitis E virus (HEV) is the causative agent of hepatitis E, an acute form of viral hepatitis. The open reading frame 2 (ORF2) of HEV encodes the viral capsid protein, which can self-oligomerize into virus-like…
Updated Oct 29, 2026
HealthData.Gov
Background Kinesins constitute a superfamily of microtubule motor proteins that are found in eukaryotic organisms. Members of the kinesin superfamily perform many diverse cellular functions such as transport of vesicles…
Updated Oct 29, 2026
HealthData.Gov
Background Differences in tea drinking habits and/or citrus peel use are likely to vary by populations and could contribute to the inconsistencies found between studies comparing their consumption and cancer risk.…
Updated Oct 29, 2026
HealthData.Gov
Background We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine…
Updated Oct 29, 2026
HealthData.Gov
Background Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts TGF-β1-mediated growth inhibition of…
Updated Oct 29, 2026
HealthData.Gov
A cell-culture model was used to establish a profile of gene expression during the effector phase of ceramide-mediated cell death. Of the 239 genes that met the criteria for differential hybridization, 10 correspond to…
Updated Oct 29, 2026