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Bench and Bedside
Bench and Bedside
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Updated Oct 29, 2026
Datasets
2,009 datasets
HealthData.Gov
24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139]
Background Early studies with desloratadine demonstrated efficacy in treating seasonal allergic rhinitis (SAR). A dose-ranging study was conducted to characterize its 24-hour efficacy in patients with SAR. Methods…
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Updated Oct 29, 2026
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Simultaneous intra/extravascular administration of antiproliferative agents as a new strategy to inhibit restenosis: The peak of reactive cell proliferation as a hallmark for the duration of the treatment
Background Strictly intravascular approaches for the treatment of postangioplasty restenosis are effective in the intima and the inner parts of the media but may be insufficient to control redundant pathways in the more…
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Updated Oct 29, 2026
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PKQuest: measurement of intestinal absorption and first pass metabolism – application to human ethanol pharmacokinetics
Background PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the differences in the area under the…
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Updated Oct 29, 2026
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Cathepsin B cleavage of the trypsinogen activation peptide
Background Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen…
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Updated Oct 29, 2026
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Training practitioners in preparing systematic reviews: a cross-sectional survey of participants in the Australasian Cochrane Centre training program
Background Although systematic reviews of health care interventions are an invaluable tool for health care providers and researchers, many potential authors never publish reviews. This study attempts to determine why…
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Updated Oct 29, 2026
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Variations in chemoprophylaxis for meningococcal disease: a retrospective case note review, analysis of routine prescribing data and questionnaire of general practitioners
Background Invasive meningococcal disease is a significant cause of mortality and morbidity in the UK. Administration of chemoprophylaxis to close contacts reduces the risk of a secondary case. However, unnecessary…
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Updated Oct 29, 2026
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Plasma proteins in a standardised skin mini-erosion (II): effects of extraction pressure
Background A standardised suction technique has been used to sample plasma proteins in dermal interstitial fluid (IF) serially for 5 to 6 days from a suction-induced skin mini-erosion. Increased protein concentrations…
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Updated Oct 29, 2026
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Model-based cluster analysis of microarray gene-expression data
Background Microarray technologies are emerging as a promising tool for genomic studies. The challenge now is how to analyze the resulting large amounts of data. Clustering techniques have been widely applied in…
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Updated Oct 29, 2026
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Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors
Background The gene expression pattern in tumor cells differs from that in corresponding normal cells. In order to identify differentially expressed genes in colorectal tumors and normal colorectal epithelium, a…
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Updated Oct 29, 2026
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Death, autoantigen modifications, and tolerance
Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms…
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Updated Oct 29, 2026
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Characterization of the mouse
Background DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor, DAZ (Deleted in Azoospermia). In vitro, DAZAP1…
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Updated Oct 29, 2026
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Distribution of serotonergic and dopaminergic nerve fibers in the salivary gland complex of the cockroach
Background The cockroach salivary gland consists of secretory acini with peripheral ion-transporting cells and central protein-producing cells, an extensive duct system, and a pair of reservoirs. Salivation is controled…
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Updated Oct 29, 2026
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Transcriptional regulation of lung development: emergence of specificity
The lung is the product of a set of complex developmental interactions between two distinct tissues, the endodermally derived epithelium and the mesoderm. Each tissue contributes to lung development by fine-tuning the…
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Updated Oct 29, 2026
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Macrophages in rheumatoid arthritis
The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if not as…
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Updated Oct 29, 2026
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The evaluation of yeast derivatives as adjuvant of the immune response to the Bm86 antigen in cattle: Correction
The evaluation of yeast derivatives as adjuvant of the immune response to the Bm86 antigen in cattle: Correction
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Updated Oct 29, 2026
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A protein folding potential that places the native states of a large number of proteins near a local minimum
Background We present a simple method to train a potential function for the protein folding problem which, even though trained using a small number of proteins, is able to place a significantly large number of native…
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Updated Oct 29, 2026
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Envelope structure of
Background Many bacteria swim by rotating helical flagellar filaments [1]. Waterbury et al. [15] discovered an exception, strains of the cyanobacterium Synechococcus that swim without flagella or visible changes in…
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Updated Oct 29, 2026
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What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
At times of crisis when epidemics rage and begin to take their toll on affected populations, as we have been witnessing with African trypanosomiasis in subSahara, the dichotomy of basic versus applied research deepens.…
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Updated Oct 29, 2026
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Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element for RT dimerization (Pandey et al., Biochemistry 40:…
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Updated Oct 29, 2026