HealthData.Gov
Background Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-receptors with self major histocompatibility complex…
Updated Oct 29, 2026
HealthData.Gov
Background This study investigates the clinical use of neuroleptics within a general hospital in acutely ill medical or surgical patients and its relation with dementia three months after admission compared with control…
Updated Oct 29, 2026
HealthData.Gov
Background Congestive heart failure (CHF) is associated with cognitive deficits, particularly of memory and attention. The present study aims to clarify whether clinical treatment can reverse the attentional deficits of…
Updated Oct 29, 2026
HealthData.Gov
We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor,…
Updated Oct 29, 2026
HealthData.Gov
Background The serum response element (SRE) in the c-fos promoter is a convergence point for several signaling pathways that regulate induction of the c-fos gene. Many transcription factors regulate the SRE, including…
Updated Oct 29, 2026
HealthData.Gov
Background: We studied the incidence of withholding or withdrawing therapeutic measures in intensive care unit (ICU) patients, as well as the possible implications of sepsis-related organ failure assessment (SOFA) in…
Updated Oct 29, 2026
HealthData.Gov
Background Laboratory experiments under controlled conditions during thousands of generations are useful tools to assess the processes underlying bacterial evolution. As a result of these experiments, the way in which…
Updated Oct 29, 2026
HealthData.Gov
RNAi can be achieved by feeding worms Escherichia coli expressing dousble-stranded RNA corresponding to a specific gene. An optimized feeding method is presented that results in phenotypes at least as strong as those…
Updated Oct 29, 2026
HealthData.Gov
Background Increased BRCA1 and BRCA2 germline mutation rates have been reported in Ashkenazi Jewish women in North America, Europe and Israel, and have been mentioned as possibly related to a higher incidence of breast…
Updated Oct 29, 2026
HealthData.Gov
Bench and Bedside
Updated Oct 29, 2026
HealthData.Gov
A detailed analysis of the anatomy and distribution of L1 elements in the human genome was carried out using a new computer program, TSDfinder, designed to identify transposon boundaries precisely. Conclusions: The…
Updated Oct 29, 2026
HealthData.Gov
Background Occupational reaction to natural rubber latex (NRL) glove use by healthcare employees has been an area of increasing concern. Unfortunately, there is little data demonstrating the prevalence and severity of…
Updated Oct 29, 2026
HealthData.Gov
Background The mammalian olfactory apparatus is able to recognize and distinguish thousands of structurally diverse volatile chemicals. This chemosensory function is mediated by a very large family of…
Updated Oct 29, 2026
HealthData.Gov
We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice caused a short-lasting, florid inflammation and…
Updated Oct 29, 2026
HealthData.Gov
Background Continuing medical education (CME) for general practitioners relies on specialist-based teaching methods in many settings. Formal lectures by specialists may not meet the learning needs of practitioners and…
Updated Oct 29, 2026
HealthData.Gov
A Leishmania model to explain microbial virulence in chronic infectious diseases is proposed. All these diseases progress from infection to symptomatic phase to host death or recovery. The outcome of each phase is…
Updated Oct 29, 2026
HealthData.Gov
Background In the United States, transjugular renal biopsies using the Quickcore™ side cut needle system have previously been described primarily for transjugular renal biopsy in patients with concurrent liver and…
Updated Oct 29, 2026
HealthData.Gov
Background Changes in the survival-rate during the larval phase may strongly influence the recruitment level in marine fish species. During the larval phase different 'critical periods' are discussed, e.g. the hatching…
Updated Oct 29, 2026
HealthData.Gov
Background Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities. Recently the MLIV gene, MCOLN1, has been identified as a…
Updated Oct 29, 2026
HealthData.Gov
Background Over 300 therapies have been proposed for premenstrual syndrome. To date there has been only one survey conducted in the UK of PMS treatments prescribed by GPs, a questionnaire-based study by the National…
Updated Oct 29, 2026