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The tradition of circulating research findings before peerreview is old and continues today. In addition to the informal circulation of non-peer-reviewed research reports between scientists, there are also…
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The abdominal compartment syndrome represents the pathophysiologic consequence of a raised intra-abdominal pressure. Various clinical conditions are associated with this syndrome and include massive intra-abdominal or…
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Pharmacology of the critically ill
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ICU resource allocation: life in the fast lane
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Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state
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Decision-making in the intensive care unit is often very difficult. Although we are encouraged to make evidence-based decisions, this may be difficult for a number of reasons. To begin with, evidence may not exist to…
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Paper reports: Combating the invasion of intensive care literature
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Background: For logistical reasons sedation studies are often carried out in elective surgical patients and the results extrapolated to the general intensive care unit (ICU) population. We question the validity of this…
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Introduction Prone position is effective in mechanically ventilated patients to improve oxygenation. It is unknown if prone position affects gastric emptying and the ability of continued enteral feeding. Aim To…
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Our goal was to compare measurement of tonometered saline and gastric juice partial carbon dioxide tension (PCO2). In this prospective observational study, 112 pairs of measurements were simultaneously obtained under…
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Introduction The purpose of this study was to note potential gynaecological risk factors leading to intensive care and to estimate the frequency, costs and outcome of management. Materials and methods In a…
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The sound of silence: rationing resources for critically ill patients
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Background Lipopolysaccharide (endotoxin) from the cell wall of Gram-negative bacteria is a potent trigger for the release of host-derived inflammatory mediators. The relationship between endotoxaemia, Gram-negative…
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Background: Although the standard tracheostomy described in 1909 by Jackson has been extensively used in critical patients, a more simple procedure that can be performed at the bedside is needed. Since 1957 several…
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Blending science and compassion: The 30th educational symposium of the Society of Critical Care Medicine, San Francisco, USA, 10-14 February 2001
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Background Venous thromboembolism (VTE) confers considerable morbidity and mortality in hospitalized patients, although few studies have focused on the critically ill population. The objective of this study was to…
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Background Computing technology has the potential to improve health care management but is often underutilized. Handheld computers are versatile and relatively inexpensive, bringing the benefits of computers to the…
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Echocardiography: a fundamental part of the intensive care curriculum
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Our current state of knowledge on noninvasive positive pressure ventilation (NPPV) and technical aspects are discussed in the present review. In patients with chronic obstructive pulmonary disease, NPPV can be…
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Objectives: To determine the degree of interinstitutional transfusion practice variation and reasons why red cells are administered in critically ill patients. Study design: Multicentre cohort study combined with a…