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TheTnfrh1gene (gene symbolTnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb…
Updated Oct 29, 2026
HealthData.Gov
Parasitic helminths of the genusSchistosomamate, achieve sexual maturity and produce eggs in the bloodstream of their definitive hosts, and the most important pathological consequences of the infection are associated…
Updated Oct 29, 2026
HealthData.Gov
Background Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of diagnostic application. Intrinsic variability of…
Updated Oct 29, 2026
HealthData.Gov
Background The honeybee (Apis mellifera) has been used with great success in a variety of behavioral studies. The lack of genomic tools in this species has, however, hampered efforts to provide genome-based explanations…
Updated Oct 29, 2026
HealthData.Gov
Background The cyclin-dependent kinase inhibitor p27Kip1 is essential for proper control of cell cycle progression. The levels of p27Kip1 are regulated by several mechanisms including transcriptional and translational…
Updated Oct 29, 2026
HealthData.Gov
DNA microarrays were used to examine the temporal program of gene expression following treatment of a human prostate cancer cell line with androgen. Significant changes in levels of transcripts of more than 500 genes…
Updated Oct 29, 2026
HealthData.Gov
The software tool PRESTA (PRomoter EST Association) is designed for efficient recovery of characterized and partially verified promoters from GenBank and EMBL libraries. The PRESTA algorithm demonstrates the principle…
Updated Oct 29, 2026
HealthData.Gov
Background Transcriptional regulation in eukaryotes generally operates at the level of individual genes. Regulation of sets of adjacent genes by mechanisms operating at the level of chromosomal domains has been…
Updated Oct 29, 2026
HealthData.Gov
Our aim was to identify specifically expressed genes using RNA arbitrarily primed (RAP)-polymerase chain reaction (PCR) for differential display in patients with rheumatoid arthritis (RA). In RA, amplification of a…
Updated Oct 29, 2026
HealthData.Gov
Background We propose two different formulations of the Rasch statistical models to the problem of relating gene expression profiles to the phenotypes. One formulation allows us to investigate whether a cluster of genes…
Updated Oct 29, 2026
HealthData.Gov
Background Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our understanding of the structure and organization of…
Updated Oct 29, 2026
HealthData.Gov
Background Affymetrix oligonucleotide arrays simultaneously measure the abundances of thousands of mRNAs in biological samples. Comparability of array results is necessary for the creation of large-scale gene expression…
Updated Oct 29, 2026
HealthData.Gov
Background The gene encoding the inorganic pyrophosphatase (PPase) of the intracellular pathogen Legionella pneumophila is induced during intracellular infection, but is constitutively expressed in Eschericia coli. The…
Updated Oct 29, 2026
HealthData.Gov
Background High density cDNA microarray technology provides a powerful tool to survey the activity of thousands of genes in normal and diseased cells, which helps us both to understand the molecular basis of the disease…
Updated Oct 29, 2026
HealthData.Gov
Background High-density oligonucleotide arrays (HDONAs) are a powerful tool for assessing differential mRNA expression levels. To establish the statistical significance of an observed change in expression, one must take…
Updated Oct 29, 2026
HealthData.Gov
Background Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally specialized fiber types of which muscle is…
Updated Oct 29, 2026
HealthData.Gov
Background Vacuolar type H+-ATPases play a critical role in the maintenance of vacuolar homeostasis in plant cells. V-ATPases are also involved in plants' defense against environmental stress. This research examined the…
Updated Oct 29, 2026
HealthData.Gov
Background: Over the past five years, interest in and use of DNA array technology has increased dramatically, and there has been a surge in demand for different types of arrays. Although manufacturers offer a number of…
Updated Oct 29, 2026
HealthData.Gov
The finding that neighboring eukaryotic genes are often expressed in similar patterns suggests the involvement of chromatin domains in the control of genes within a genomic neighborhood.
Updated Oct 29, 2026
HealthData.Gov
Background NGF exerts a variety of actions including promotion of neuronal differentiation and survival. The PC12 rat pheochromocytoma cell line has proved valuable for studying how NGF works and has revealed that the…
Updated Oct 29, 2026