Datasets

4 datasets

HealthData.Gov

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in

RNAi can be achieved by feeding worms Escherichia coli expressing dousble-stranded RNA corresponding to a specific gene. An optimized feeding method is presented that results in phenotypes at least as strong as those…

HTML

Updated Oct 29, 2026

HealthData.Gov

Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

Background Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic…

HTML

Updated Oct 29, 2026

HealthData.Gov

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

Background Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on non-nuclear genes and its effect on the…

HTML

Updated Oct 29, 2026

HealthData.Gov

Doxycycline-induced expression of sense and inverted-repeat constructs modulates

Background A tetracycline-regulated (conditional) system for RNA interference (RNAi) would have many practical applications. Such a strategy was developed using RNAi of the gene for phosphogluconate mutase (Pgm). Pgm is…

HTML

Updated Oct 29, 2026